Controlling Calcium Entry
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چکیده
منابع مشابه
Controlling Calcium Entry
Ca(2+) enters cells through an assortment of Ca(2+)-permeable channels that respond to different stimuli and couple to different cellular responses. Several different Ca(2+) entry pathways can be activated by receptors that stimulate phospholipase C (PLC). Both limbs of this signaling pathway (IP(3) and diacylglycerol), PLC itself, and its substrate (PIP(2)) contribute to the coordinate regulat...
متن کاملCapacitative Calcium Entry.
Capacitative Ca(2+) entry is a recently discovered Ca(2+) entry pathway that is activated on depletion of intracellular Ca(2+) stores, providing an avenue for store refilling. Despite recent progress in elucidating the capacitative Ca(2+) entry pathway, the mysteries of its molecular identity, its biophysical properties, and the store depletion signal remain.
متن کاملCapacitative calcium entry
A long-standing mystery in the cell biology of calcium channel regulation is the nature of the signal linking intracellular calcium stores to plasma membrane capacitative calcium entry channels. An RNAi-based screen of selected Drosophila genes has revealed that a calcium-binding protein, stromal interaction molecule (STIM), plays an essential role in the activation of these channels and may be...
متن کاملCapacitative calcium entry.
The original idea that calcium might enter cells through a capacitative mechanism was first introduced by Jim Putney [1]. The somewhat surprising hypothesis was that calcium entry was regulated by the state of filling of the calcium stores. By analogy with a capacitor in an electrical circuit, the calcium stores prevent entry when they are charged up but immediately begin to promote entry as so...
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Glutamate, the major excitatory neurotransmitter in the mammalian central nervous system (CNS), activates two types of ionotropic glutamate receptors (GluRs). According to their pharmacological properties, they are termed ~-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)/kainate receptors (or non-NMDARs) and N-methyl-D-aspartate receptors (NMDARs). The two types of receptors differ in sev...
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ژورنال
عنوان ژورنال: Cell
سال: 2002
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(02)01197-2